619 CP31398, which reverses UV-induced p53 mutations, does not undo ultraviolet radiation-induced immune suppression

Chronic, excessive exposure to solar ultraviolet radiation is the major causative agent for cutaneous squamous cell carcinomas. Mutations in p53 are essential these cancers develop. UV also immunosuppressive and an additional requirement UV-induced SCCs can be reversed with compound CP31398, which results fewer mice exposed a skin carcinogenesis protocol. It unknown whether mutations contribute photoimmunosuppression. The purpose of this study was determine if effects could by pretreatment CP31398. A local UVB regimen consisting (200 mJ/cm2) 4 days followed sensitization hapten 2, 4, dinitrofluorobenzene (DNFB) employed To role CP-31398, we treated shaved dorsal C57BL/6 CP-31398 (1.25 mg/mouse) or vehicle cream, 30 min before each treatment. Treatment did not abrogate effect UV. These findings suggest that although responsible SCCs, they necessary immunosuppression.